Oral medicine for ED also might not be safe or work well if you have: Very low blood pressure, called hypotension, or uncontrolled high blood pressure, called hypertension. This is important for your overall health and safety, as certain medications can negatively interact with each other or cause existing conditions to worsen. A newer form of the medicine that dissolves on the tongue might work faster than the pill that you swallow. Severe liver disease. Kidney disease that needs to be treated with dialysis. Most companies have an FAQ or shipping policy page you can reference to learn whether discreet packaging is available.Oral medicines for ED usually work well and cause few side effects. The four main medicines taken by mouth for erectile dysfunction are: Avanafil (Stendra). Sildenafil . For now, we’ll check out the oral options available by prescription only. The oral prescription meds used to treat ED are called PDE-5 inhibitors. ED pills are sold under brand names . Levitra (vardenafil hydrochloride) is an oral medication taken to treat erectile dysfunction (ED). It’s in the same class of drugs as other popular ED medications, .