To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and site usage information with other information we have about you. These include itraconazole Sporanox, Tolsura , ketoconazole Extina, Ketozole, others and ritonavir Norvir. Recent heart or blood vessel problems. These medicines are called PDE5 inhibitors. The ability to develop and maintain an erection is largely governed by sexual arousal, a complex process that involves the brain, hormones, emotions, nerves, muscles, and blood vessels. These are: conditions affecting the flow of blood to your penis — vasculogenic conditions affecting your nervous system, which is made up of your brain, nerves and spinal cord — neurogenic conditions affecting your hormone levels — hormonal conditions affecting the physical structure of your penis — anatomical Injuries and surgery Penis injuries or surgical treatment of the penis, pelvis or surrounding areas can sometimes lead to erectile dysfunction. Kidney disease that needs to be treated with dialysis. · For oral dosage form (tablets): Adults up to 65 years of age—50 milligrams (mg) as a single dose no more than once a day, 1 hour before sexual intercourse. . Medical conditions Older males are more likely to have medical conditions contributing to ED. Examples of health conditions include: diabetes heart disease high blood pressure . The Savings Offer and Program expire on 12/31/ For further information, call , visit , or write: Viatris Inc., P.O. Box , Mission, KS .